Mesterolone (Proviron) Structure

 

For this reason Proviron is not one of the those compounds that you will use for mass building or bulking, but it can still have some specific purposes for bodybuilders and some benefits that will interest those who make use of other anabolic steroids.The lack of anabolic effects is why Proviron is sometimes named simply as an androgen rather than an anabolic steroid and is the reason why this isn’t a compound to use for mass gaining; simply increasing the dose and hoping it will deliver muscle gains is not the way to use Proviron but it can be an easy mistake for a beginner to make with any steroid.

 

This is an oral product based on dihydrotestosterone (DHT) with some modifications. The weak anabolic effects of Proviron come about because of the way it is broken down and made inactive once it is in the muscle tissue – something that also occurs with DHT itself.

 

In many ways, Proviron is a very unique anabolic steroid. It shares some strong similarities to Masteron (Drostanolone) and to a degree Anavar (Oxandrolone) and Winstrol (Stanozolol) but in totality it is its own unique animal. In a performance capacity, Proviron is not used to promote large buildups in mass, although it can serve an important purpose during such a phase of training. We will, however, find Proviron to be far more common in cutting cycles, but once again its purpose will be somewhat unique.

 

As a therapeutic agent, the primary purpose of use is treating androgen deficiencies, age being the most common culprit of the condition. It is, however, also used in pre-pubescent males as well. The hormone is also used as a fertility aid in men and this alone makes it a very unique anabolic steroid as most anabolic steroids tend to have the opposite effect.
 

Mesterolone is a dihydrotestosterone (DHT) derived anabolic androgenic steroid. Specifically it is a structurally altered DHT hormone possessing the addition of a methyl group at the carbon one position. This allows the hormone to survive oral ingestion by protecting it from hepatic breakdown. This is one of the only oral anabolic steroids that is not C17-alpha alkylated (C17-aa) but instead carries the added methyl group. Oral Primobolan is the other most well-known oral steroid that carries this same methyl group. While the added methyl group does in fact protect it from breakdown, the total bioavailability of Proviron will be far less than most all C17-aa oral steroids. For this reason it has fallen out of popularity among many performance enhancing athletes.

 

Proviron carries an androgenic rating of 30-40 and an anabolic rating of 100-150. Despite having an anabolic rating that is potentially greater than testosterone, Proviron will display very low anabolic traits. This is very similar to Halotestin (Fluoxymesterone), which carries a massive anabolic rating but very little translatable anabolic activity. In the case of Proviron, while structurally very anabolic, the Mesterolone hormone converts and reduces to Diol metabolites, in turn reducing anabolic activity. However, Proviron’s androgenic rating is a different story. In fact, its translatable androgenic activity appears to commonly be higher than its structural rating would imply.

 

On a functional basis, Proviron carries four primary traits that largely define its mode of action. First and foremost the Mesterolone hormone has a strong binding affinity to Sex-Hormone-Binding-Globulin (SHBG). In fact, it appears to be one of the strongest anabolic steroids in this regard. By binding to SHBG, a hormone partially responsible for reducing free testosterone, binding SHBG will enhance the amount of circulating free testosterone. More importantly for the anabolic steroid user, it will make a larger percentage of the anabolic steroids used available in a free rather than bound state. A simple way to look at it is the anabolic steroids you’re taking become more powerful and potent.

 

Proviron also has the ability to interact with the aromatase enzyme, the enzyme responsible for the conversion of testosterone to estrogen. By binding to the aromatase enzyme, Proviron can actually inhibit aromatase activity, thereby offering protection against estrogenic side effects. Depending on the nature of the cycle the individual undertakes it is quite possible for Proviron to take care of all your anti-estrogen needs.

 

The Mesterolone hormone will also carry a strong binding affinity to the androgen receptor. Once again this will promote the functionality of other steroids to a degree but more importantly promote enhanced metabolic activity through direct lipolysis. 

Then we’re left with the final issue that surrounds Proviron as a fertility medication. This is an anabolic steroid that does not suppress gonadotropins similarly to other anabolic steroids. With minimal suppression and its extremely strong androgenicity, this will enhance sperm production as androgens are necessary to spermatogenesis stimulation. This not only enhances the amount of sperm produced but greatly and equally important enhances the quality of the sperm. 

 

During a bulking phase Proviron is not going to be a foundational steroid. Adding in Proviron could possibly help the individual breakthrough a sticking point during his cycle. At some point and time in all cycles the progress begins to wane, and in some cases come to a complete halt. By the way Proviron enhances the total free state of the other steroids being used in a stack, it could possibly help the individual breakthrough this sticking point. During the off-season, this is where most will use the largest amount of testosterone. Many will use large amounts during cutting cycles too, especially competitive bodybuilders but lower testosterone plans are more common during the cutting phase. However, there are those for numerous reasons who choose to run off-season cycles with limited testosterone doses. In such plans, including Proviron could give them a slight needed androgen boost. While it may not always be necessary it could prove to be beneficial.

 

Without question the best time to use Proviron will be during the cutting phase. This steroid has the ability to provide a bit of a hardening effect similar to Masteron, but more importantly the hardening effects of other steroids will be enhanced. Then we consider its strong binding to the androgen receptor, which will in fact enable the individual to burn body fat at a far more efficient rate. From here we must consider the anti-estrogen effect of Proviron. This will ensure the individual is less prone to water retention and as discussed, depending on the total cycle, it could negate the need for a traditional anti-estrogen. Then we’re once again left with the enhancement of circulating free testosterone. This can be a tremendous benefit when testosterone levels are often much lower during this phase of anabolic steroid use. In fact, with a low dosed testosterone cycle that includes other anabolic steroids, we can confidently say the total results will be greater for the individual who includes Proviron compared to the one who does not. In the end, the primary base benefit is the increased androgenicity of other steroids being used in order to promote a much harder and far more defined physique. 

 

Although Proviron is most commonly used by people who would be classed as advanced users – competitive bodybuilders – some people at the beginner level might still consider adding it to a cycle to evaluate results. There is little risk in doing so and since Proviron is quite effective when used for short periods of time, provides a good introduction on how to use an ancillary compound.

  

In fact, taking the exact same or similar dose as is medically prescribed for androgenic treatment is still highly effective for bodybuilders. A daily dose of between 50mg per day at a minimum, up to 150mg per day maximum is more than sufficient for the mitigation of estrogen related effects like water retention.

 

Regardless of experience level, Proviron is included in a cycle mainly to mitigate the estrogenic effects of other steroids. This means that your dosage of Proviron is going to heavily depend on which other compounds you’re using.

 

All experience levels from beginners right up to advanced users will want to stay within the same dosage range for Proviron, with 50mg daily being the minimum dose and 150mg daily as the maximum. Even though Proviron is considered quite safe up to 250mg per day, going beyond 150mg each day comes with little to no increased benefits but a higher risk of negative side effects and such high doses are only considered by the most advanced and competitive of users.

 

Proviron comes in 25mg tablets so your daily dosage is made up of 25mg increments. If taking 3 tablets daily for a 75mg dose, it’s recommended to spread the administration out throughout the day and not to take all three tablets at once because the compound has an active life of just 8 to 12 hours so regular administration is needed to maintain optimal blood levels.

 

The manufacturer of the original Proviron states that the tablets can be taken either with or without food, but that it is most ideal to take the tablets as close to the same time each day as possible so your circulating levels of Proviron are maintained as efficiently as possible.

 

The timing of your Proviron administration will completely depend on the purpose of your use: do you want to use it throughout a steroid cycle for estrogen mitigation as a mild aromatase inhibitor compound, or are you looking for some hardcore physique hardening effects at the pre-contest stage?

 

It’s very common for competitive bodybuilders to use Proviron at higher doses of 150mg and sometimes more at the stage of being close to a contest. This allows androgens to quickly increase and a very hard, solid and dry look can be achieved in this final stage, especially if lower androgenic cutting steroids like Anavar and Winstrol have been used to get you lean and cut combined with a serious calorie controlled diet. Those who are not already very lean near the end of a cutting cycle will see less benefits from Proviron. Body fat should be considerably low at this point, allowing Proviron to take hold to exert its fluid removal and hardening effects. Without a very lean and cut physique, these effects will be difficult to notice.

 

Even though the risks of females using Proviron are well known, some women still choose to use it to gain physical enhancements. In these cases, a low dose and limited cycle length are critical to minimize virilization side effects. Females should not exceed 25mg daily of Proviron with a cycle length of no more than 5 weeks. Many females will still find virilization is still an issue at this low level of Proviron usage simply because it is a strong androgen and a DHT derived compound whose androgenic side effects can not be mitigated through the use of any anti-androgenic drugs.

 

 

Proviron’s anti-estrogen ability helps mitigates some of the estrogenic activity of other steroids while contributing to goals like gaining a hardened physique, once again because of the anti-estrogen qualities that help reduce water retention. Below are some of the example cycles where Proviron can be included for great benefits:

 

Beginner steroid users will almost always be starting with a testosterone compound and this is where you will include Proviron for added benefit. In any case, using Proviron alone is never recommended nor beneficial, due to its suppressive effects and its lack of ability to deliver truly desirable results as a standalone compound.

 

So as a beginner you can safely add Proviron to your existing testosterone cycle at 50mg daily and expect to see some impressive hardening effects, as well as an increase in the effectiveness and results from the testosterone itself as more of it is freed up while Proviron binds to the SHBG protein.

 

 

Any level of user will see good results even at the 50mg daily level with Proviron and for many intermediate users this can be as far as you want to take it. However it will largely depend on what steroids are being used in your cycle and whether your main goal is for maximum muscle hardness or to use Proviron mainly to mitigate estrogenic side effects.

 

Stacking with your regular testosterone cycle will provide highly beneficial for the intermediate user as you will gain the great benefit of increased testosterone being available in the bloodstream while Proviron binds to SHBG. If your goal with Proviron is to inhibit aromatization then it’s safe to use this compound for a 12 week cycle if desired.

 

The most advanced steroid users should still not exceed 150mg daily of Proviron. Most advanced users will likely be aiming to use Proviron to provide a last minute hardening boost near the end of an intense cutting cycle or as pre-contest preparation.

 

The advanced user will already be significantly lean and cut, will have controlled water retention well during a cutting phase that makes use of compounds like Clenbuterol, testosterone, Winstrol, and Anavar. In this scenario, the advanced user will benefit greatly from Proviron’s additional reduction in fluid build up towards the end of the cycle.

 

Proviron is able to be stacked with just about any anabolic steroid but its best use is when you combine it with other steroids commonly used in a cutting cycle. These include Masteron, Anavar, Trenbolone and Winstrol.

 

Anyone considering using Proviron should know that this is not a bulking steroid. Not all steroids are beneficial for gaining mass and this is one that falls into another category in terms of its usefulness. In fact this is a steroid that is rarely used to give you direct results itself, but instead to work with the other compounds you’re using in what is known as an ancillary compound.

 

 

As a result of rising estrogen levels through the use of other aromatizing steroids like testosterone, Proviron can help slow or even halt these other steroids from aromatizing which prevents conversion to estrogen. This is achievable even at a low dose of 50mg each day which can greatly help reduce or hold off the gynecomastia and fluid retention caused by other aromatizing steroids. The result is a physique that is noticeably harder and drier – exactly what is required in a cutting and contest preparation phase.

 

 

While Proviron itself comes with minimal or even no noticeable testosterone suppression at doses that are effective for performance enhancement, almost everyone will use this steroid with other compounds that do suppress natural testosterone production. Therefore a PCT plan will still almost always be required to get your normal testosterone function stimulated again and to avoid falling into a state of low testosterone where muscle loss and fat gain occurs, among other serious symptoms.

 

Proviron itself is sometimes utilized in PCT since one of its medical uses is to enhance fertility. By using Proviron in PCT to reduce estrogen, the recovery of testosterone might be improved but this needs to be weighed up with Proviron’s tendency to mildly reduce natural testosterone. So while some people might choose to use Proviron during PCT because they can’t access other better PCT drugs like SERMs, it is generally not advisable for best results.

 

There are possible side effects of Proviron use; however, this steroid carries one of the highest safety ratings among all anabolic steroids. Most men will be able to use this steroid without any negative issue, but possible side effects do exist despite a low probability. When it comes to female use, in a therapeutic or performance capacity this steroid cannot be recommended. The rate of virilization is much to high and should be avoided by females who wish to protect their femininity. 

The Mesterolone hormone is not estrogenic. It does not aromatize and it carries no progestin nature. As a result, the side effects of Proviron will not include any related effects such as gynecomastia or excess water retention. Such adverse effects are impossible with this steroid. This will also greatly reduce the risk of high blood pressure as high blood pressure associated with anabolic steroid use is often due to extreme water retention. In fact, Proviron should provide an anti-estrogenic effect by preventing testosterone to estrogen conversion or at least tremendously slow it down.

 

The side effects of Proviron can include those of an androgenic nature. This shouldn’t be surprising when we consider androgenic action is this steroid’s primary purpose. Such side effects of Proviron can include acne, accelerated hair loss in those predisposed to male pattern baldness and body hair growth. Such effects are highly dependent on genetic predispositions. For example, those who are not genetically prone to male pattern baldness will not lose any hair. Those who are not sensitive to acne should not have any issues with breakouts.

 

Due to the potent androgenicity of Proviron, it will lead to severe virilization in women. This can and will more than likely include body hair growth, a deepening of the vocal chords and clitoral enlargement. Women are highly cautioned against using this anabolic steroid. There are several steroids that carry much lower virilization ratings such as Anavar and Primobolan. Such steroids should always be a female’s first choice.

 

Cardiovascular strain, particularly cholesterol issues will be the most concerning side effect of Proviron. This anabolic steroid can negatively affect cholesterol at a pronounced rate than most anabolic steroids. If you suffer from high cholesterol you should not touch this steroid. If you are healthy enough for use you will need to keep a close eye on your levels. A very cholesterol friendly diet is imperative. This should include an abundant amount of omega fatty acids; you should be supplementing with large amounts of fish oils every day. The individual’s diet should also be extremely limited in saturated fats as well as simple sugars. A cholesterol antioxidant is also recommended when using Proviron. While annoying to some, you should also include plenty of cardiovascular training into your routine. 

 

All anabolic androgenic steroids are suppressive to natural testosterone on some level. The rate of suppression varies greatly between steroids and with Proviron it can be very minimal. Studies have shown that it’s more than possible to use the Mesterolone hormone without any significant reduction in natural testosterone production. This doesn’t mean it’s not suppressed at all, it simply means it’s minimal and rather inconsequential. A total dosing of 150mg per day or less should not have a notable effect on natural testosterone production. Due to minimal testosterone suppression, it is possible to use this anabolic steroid without exogenous testosterone or at least with a very minimal amount. 

 

Regardless of the specifics of the cycle, once all anabolic steroid use has come to an end natural testosterone production will begin again. Most are encouraged to implement a Post Cycle Therapy (PCT) plan at this stage. A PCT plan will speed up the recovery process; however, it will not return you to normal on its own. Total recovery will take time but it will take much longer without a PCT plan. With a PCT plan, you will ensure you have enough testosterone for proper bodily function while your levels continue to naturally rise over time. It should be noted; natural recovery assumes no prior existing low testosterone condition. It also assumes no severe damage was done to the Hypothalamic-Pituitary-Testicular-Axis (HPTA) due to improper anabolic steroid use.

 

Despite being an oral anabolic steroid, Proviron is not hepatotoxic. This is not a C17-aa anabolic steroid and will not burden the liver with any stress or damage.

 

In a performance capacity, Proviron doses normally range from 50-150mg per day. Most men, however, will find 100mg per day to be the minimum beneficial dose with both 100mg and 150mg being highly effective. Total use will normally last between 8-12 weeks. However, in an effort to breakthrough a sticking point in a cycle, say towards the end of a cycle a 6 week course of Proviron may do the trick.

 

When you’re planning your Proviron use, you will find it stacks well with all anabolic steroids. During the cutting phase it will be most beneficial in conjunction with steroids like Anavar, Masteron and Winstrol as well as Primobolan. It will greatly promote the androgenicity of these steroids in order to provide and promote the hard look desired. In a bulking phase, while it will stack well with all anabolic steroids it’s hard to say if you’ll need it or not. Some will simply keep it on hand and include it when it proves to be possibly necessarily beneficial.

 

The steroid laws of the U.S. are some of the harshest the world over. There are countries that carry laws that are similarly strict but there are numerous that are far more lenient. China and some other countries are heavens for anabolic steroids and other performence-enhancing products. It is imperative you understand the law as it pertains to where you live before you buy any anabolic steroids. Due to the steroid laws of the U.S. and other parts of the world, if you are looking for high quality anabolics or SARMs you are encouraged to visit www.ultrapandaroids.com, which has 3 warehouses located in USA, Hong Kong, and Italy. Ultrapandaroids.com can legally provide you high quality anabolics without a prescription. 

 

Proviron is not what we can call an extremely powerful anabolic steroid. However, this is still a very beneficial anabolic steroid. It’s simply not beneficial in the traditional way in which we often view anabolic steroids. If used for the right purposes and with an understanding of the hormone, Proviron could potentially transform many of your cycles. Will this be the end all be all that sees a radical transformation acquired? Probably not, but it will provide benefits that others steroids cannot and simply round out your cycle in a way that will be hard to beat.

 

 

 

Unlike many other oral steroids, Proviron does not come with the risk of liver toxicity. That’s because Proviron is not a 17 alpha-alkylated anabolic-androgenic steroid (17alpha-AAS) and it is only oral steroids in that category which come with a very high risk of hepatotoxicity and liver damage. But since you will almost certainly be using other steroids in your cycle, some of which might come with their own toxic effects to the liver, this is an issue that should always be considered when using any steroid.

 

All steroids come with their own risks, especially when they are misused by using them in very high doses or for extended periods of time. Proviron is considered one of the safest steroids available with relatively mild side effects compared with many more powerful steroids. Even though Proviron is an oral steroid, it does not cause damage to the liver which is another reason this steroid is thought to be one of the least harmful.

 

Proviron is used for specific purposes during a steroid cycle and only if you understand what it can do and whether you will benefit from it should you then decide whether to include Proviron during your cycle. While it is possible and entirely safe to include Proviron during an entire 8, 10 or even 12 week cycle with other steroids, just doing so without understanding why will bring you no benefits.

 

For many people, Proviron’s greatest power is in its excellent hardening effects and for many people it might only be necessary to include Proviron in the final couple of weeks of a cycle rather than for the entire cycle. Exactly how and when you use Proviron during your cycle should be a decision made based on your own personal goals and the potency of other steroids being used.

 

Proviron acts as a mild aromatase inhibitor so by that nature it has some estrogen block effect. It needs to be known though that you won’t find this estrogen blocking effect as strong as it is with true AI drugs like Arimidex, but it does come with great benefits for steroid users because increased estrogen is the cause of gyno and water retention, so Proviron can greatly help combat these, leading to increased muscle hardness with a low concentration of estrogen in the blood.

 

Proviron can play a very beneficial role in cutting phases. It can enhances physique hardness which comes along with mitigating estrogen, as it’s the estrogenic effects of steroids that bring about water retention and that bloated look we all want to avoid.

 

With its anti-estrogen activity, Proviron is able to offset this and help you retain a much harder, drier look which is why its most often used for cutting purposes. Proviron itself can also contribute to hardening but the most power lies in its ability to amplify the hardening effects that you gain from other steroids and that’s why it’s often included near the end of a cycle rather than used throughout the entire cycle.

 

Proviron does not have a powerful suppressive effect on natural testosterone function. It can have cause some mild suppression but nowhere near the level of many other steroids which can often shut down testosterone function completely.

 

At a reasonable dose that does not exceed 150mg daily, the suppressive effects of Proviron are unlikely to be noticed by most users. However since almost everyone will use Proviron with other steroids that do cause much more severe suppression, that will still likely need to be dealt with both during and after your steroid cycle.

 

Proviron has a number of very useful functions for bodybuilders and anyone serious about physique enhancement, including for contests. It is able to reduce the fluid build up caused by other steroids because of its anti-estrogen properties. It is able to help free up circulating testosterone by binding to the protein that otherwise has testosterone binding to it.

 

Proviron is very useful as both a mild and effective aromatase inhibiting compound during a cycle, or to use as a powerful last minute hardener towards the end of a hardcore cutting cycle where fluid retention needs to be at the lowest possible level.