#-057 Letrozol(Femara)
Letrozol Product Profile:
Alias: Femara
Function: Aromataze Inhibitor
MF: C17H11N5
MW: 285.3
Purity: 99%
Appearance: white powder
What is Letrozole (Femara)?
Like most of the AIs we look at for using alongside anabolic steroids, Letrozole was also developed for the medical treatment of breast cancer in post menopausal women.
Letrozole Structure
The reason it is only used in women of such an age is due to its powerful estrogen blocking ability which would have serious health implications for pre-menopausal women, but for male steroid users in particular it is this trait that makes AIs like Letrozole so appealing as we aim to combat the adverse effects of estrogen when using aromatizing steroids.
Letrozole is able to lower your overall estrogen levels because it blocks the aromatase enzyme. This is in contrast to the other popular category of estrogen control drugs for steroids users, SERMs, which only target very specific areas of the body. This allows Letrozole to combat a wider range of estrogenic side effects caused by steroids, with the two main ones being gynecomastia and water retention. This will also help prevent the high blood pressure that can come along when excess water retention is not addressed.
Letrozole is an anti-estrogen of the Aromatase Inhibitor (AI) family and is one of the most potent and powerfully effective of all AI’s. In fact, its potency is sometimes too much for some to handle when used for off label use. In fact, it would prove to be virtually identical to the already popular AI in Arimidex (Anastrozole). While intended for breast cancer treatment, like many AI’s, it has found a welcomed home among anabolic steroid users. Letrozole is one of the most commonly used anti-estrogens among steroid users during steroid use to combat possible estrogenic related side effects. It is so effective as an anti-estrogen in this regard many anabolic steroids have effectively reversed gynecomastia symptoms with Letrozole.
Letrozole Functions & Traits
Letrozole is an AI, which holds the purpose of blocking the aromatase enzyme, which is in turn responsible for the production of estrogen. By inhibiting estrogen production, this lowers total serum estrogen levels in the body. It will be beneficial to the anabolic steroid user as excess estrogen often leads to some of the most commonly associated side effects of steroid use.
Letrozole also carries the ability to increase natural testosterone production through an increase in Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH). There have been physicians who have chosen Letro as it’s often known to treat low testosterone conditions, but this is normally not the preferred method of treatment. Without question, when it comes to low testosterone treatment exogenous testosterone is generally the only thing that makes sense. However, Letrozole can be useful in such a plan in conjunction with exogenous testosterone in order to combat possible side effects. We will look into this in the effects section.
Effects of Letrozole
For the anabolic steroid user, the anti-estrogenic effect provided by Letrozole is tremendously beneficial. Many anabolic steroids have the ability to increase estrogen levels due to testosterone’s interaction with the aromatase enzyme. As estrogen levels rise, this can lead to gynecomastia and excess water retention. If water retention becomes severe, this can in turn promote high blood pressure. While many anabolic steroids have the ability to aromatize and promote an increase in estrogen, not all anabolic steroids carry this ability. However, many common steroids carry this ability including Methandrostenolone (Dianabol) as well as all forms of testosterone. The Nandrolone (Deca Durabolin, Durabolin, NPP, etc.) and Boldenone (Equipoise) hormone also carry the ability to aromatize to a degree. Nandrolone will aromatize at approximately 20% the rate of testosterone and Boldenone at approximately 50%. While both aromatize significantly less than testosterone, it is enough to promote estrogenic related side effects. The probability is increased with Nandrolone as it carries a strong progestin nature. Progesterone has the ability to stimulate the estrogenic mechanism and can lead to gynecomastia. AI’s like Letrozole can be useful when using all the aforementioned steroids.
By including Letrozole in a cycle that contains aromatizing anabolic steroids, this can prevent the estrogenic related side effects. This will protect the individual from gynecomastia and water retention. Further, while many steroids can promote high blood pressure despite aromatization, an AI will improve the individual’s odds when water retention is the culprit. Heavy excess water retention is normally the number one cause of high blood pressure among steroid users.
Undeniably, AI’s like Letrozole are the most effective means at combating estrogenic related side effects. However, they can also have a negative impact on cholesterol. Alone AI’s do not appear to have a strong, negative effect on cholesterol, but when coupled with an aromatizing steroid like testosterone the adverse cholesterol effect is enhanced. For this reason, many will find SERM’s like Tamoxifen Citrate (Nolvadex) should be their first choice in estrogen protection. SERM’s will not negatively affect cholesterol; in fact, SERM’s, while anti-estrogenic, actively act as estrogens in the liver, and in turn, promote healthier cholesterol levels. We’ll look at this in more detail in the side effect section, and while Letrozole can be used without an adverse cholesterol effect, it will take some effort on your part.
With its ability to promote natural testosterone production, Letrozole is often an appealing choice for Post Cycle Therapy (PCT) plans. This can also make it appealing for low testosterone treatment, but it’s often not enough. However, for PCT purposes, while it can be effective it’s generally not recommended. For the anabolic steroid user, his best bet for PCT is sticking with SERM’s for his natural testosterone production needs.
Side Effects of Letrozole
The side effects of Letrozole will cover a wide breadth and will be very similar to Arimidex. Both weakness and fatigue are two of the most common side effects of Letrozole use. However, for the anabolic steroid user this will normally not be an issue. The use of anabolic steroids should prevent such states so as long as estrogen suppression isn’t taken too far. Beyond possible energy issues, the most common side effects of Letrozole use include:
Headaches
High Blood Pressure
Hot Flashes
Joint Pain
Depression
Letrozole has also been shown to have the ability to notably decrease bone mineral content, which could increase the risk of osteoporosis. This should, however, not be a big risk for the anabolic steroid as most steroids have the ability to promote bone mineral content to a degree, especially Nandrolone. As with all medications and anything we put into our body, the side effects of Letrozole will largely surround possible and not guaranteed. We are all different and respond to varying substances differently. This is something you need to keep in mind, and if the side effects of Letrozole prove to be too much to handle, alternative medications should be looked at.
The final side effect of Letrozole surrounds cholesterol, specifically a reduction in HDL cholesterol. Alone it does not appear to have a strong, statistical impact, but for the anabolic steroid user this can be a concern. Many anabolic steroids already have the ability to negatively affect cholesterol. Due to the possible adverse effects on cholesterol, especially for the anabolic steroid user, a cholesterol friendly lifestyle becomes imperative. A healthy lifestyle will greatly revolve around your diet. Simple sugars and saturated fats should be limited and omega fatty acids should be a large part of your diet. Daily fish oil supplementation is recommended. Many may also find a cholesterol antioxidant supplement to be useful. Further, implementing plenty of cardiovascular activity into your routine is very important. Some type of daily cardiovascular activity is advised.
Letrozole Administration
For the anabolic steroid user, if gynecomastia symptoms begin to show 7-14 days at a dose of 2.5mg per day can reverse the symptoms. Once symptoms begin to fade away the individual should be able to tapper down to a more manageable dose and maintain it for the remainder of the cycle. If this doesn’t work there’s a good chance the symptoms have already set in beyond remedy. When this happens the only thing that will remove your gynecomastia is surgery. For standard estrogenic related protection, most men will find 0.5-1mg every other day to be more than enough. When used as an anti-estrogen in low testosterone treatment plans, even less may be needed. For the competitive bodybuilder, the final 7-14 days before competition, a full 1mg per day leading up to the show can be a solid dose and will greatly help with dryness and a tighter look.
Making use of Letrozole alongside Nolvadex, which is a staple in PCT for most men, results in both drugs making the other less effective. Combining these drugs is not recommended for PCT and therefore most people will opt simply to use the better PCT option in the SERM Nolvadex while enjoying the benefits that Letrozole can provide during the steroid cycle only.
Buy It Online
The steroid laws of the U.S. are some of the harshest the world over. There are countries that carry laws that are similarly strict but there are numerous that are far more lenient. China and some other countries are heavens for anabolic steroids and other performence-enhancing products. It is imperative you understand the law as it pertains to where you live before you buy any anabolic steroids. Due to the steroid laws of the U.S. and other parts of the world, if you are looking for high quality anabolics or SARMs you are encouraged to visit www.ultrapandaroids.com, which has 3 warehouses located in USA, Hong Kong, and Italy. Ultrapandaroids.com can legally provide you high quality anabolics without a prescription.
Letrozole Reviews
There are several AI’s available on the market. Arimidex is probably the most common AI with Aromasin (Exemestane) gaining a lot of popularity in recent years. However, there are many who find Letrozole to be the most effective. In the end, many will simply need to try all three at different times to find which one works best for them. You will never need all three and even if you end up preferring Arimidex or Aromasin you will find Letrozole should still work for almost anyone.
Common Q&A Related to Letrozole>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
Does Letrozole cause fatigue?
Taking Letrozole at too high of a dosage will cause a noticeable onset of fatigue and general lack of energy; something that no athlete or bodybuilder wants to experience. This is just one reason why it’s essential to stick to the lowest possible dose that still gives you the intended benefits, without causing this or other side effects which will seriously hamper your performance and results and outweigh any benefit that Letrozole can provide you.
Can you drink alcohol while taking Letrozole?
Drinking alcohol while taking steroids (and even when not) is not something any serious bodybuilder or athlete wants to do as alcohol is a well known performance decreaser, health hazard, liver stressor and so many more negative things. Alcohol and medications are never a wise mix either, with interactions between two being very possible. When it comes to Letrozole, drinking alcohol alongside use of the drug is known to increase the risk of headaches and nausea as both substances individually can cause these effects; when combined these issues can become more pronounced.
Which is better Clomid or Letrozole?
Clomid (clomiphene citrate) is another drug often used by steroid users. Unlike Letrozole which is an aromatase inhibitor, Clomid is a selective estrogen receptor modulator (SERM). Both drugs are very effective but they work differently, so one can not be said to be better than the other.
If you want an AI, Letrozole is possibly the best at controlling estrogen symptoms while you’re on a steroid cycle while Clomid is a standard choice for PCT use. Letrozole is effective at lowering overall estrogen so is excellent for both water retention control and gyno, while Clomid specifically targets the breast tissue.
For PCT usage, Clomid is considered a better choice because it does not suppress overall estrogen levels the way that Letrozole does which provides a better hormonal balance for restoring your normal testosterone production after a steroid cycle. By comparison, Letrozole is generally considered too powerful as an estrogen reduction drug to be a good choice for PCT.
Letrozole vs Arimidex for PCT?
Letrozole and Arimidex are very similar compounds. Both are nonsteroidal aromatase inhibitors and both are favored by anabolic steroid users to prevent estrogenic side effects. Both drugs have a similar side effect risk profile. Out of the these two AIs, Arimidex generally takes the lead as being more widely used by bodybuilders but this can come down to a number of factors including availability, cost, and wanting to follow in the path of what friends and online acquaintances might recommend.
While both of these AIs can help stimulate natural testosterone production, neither are considered by most guys to be the right choice for PCT when used alone; in fact many people won’t use a powerful AI like Arimidex or Letrozole during PCT at all and instead go for a SERM drug with Nolvadex being a popular choice, alongside Clomid and often hCG as well.
The main reason for this is that Arimidex is very good at lowering estrogen, and Letrozole even more so. They are so powerful at this task that they can result in estrogen levels that are too low even for the male body. This causes complications in the hormonal balance and will have a negative impact in your natural testosterone recovery; males still need a small amount of estrogen to keep things in balance and since PCT is all about getting your natural hormone function back to normal, continuing with a high estrogen suppression drug like Letrozole or Arimidex after the steroid cycle can make this difficult, if not impossible.
Another issue when considering the use of Letrozole during PCT is that when it is combined with the staple PCT drug of choice for most people, Nolvadex, a negative interaction occurs where the concentrations of drugs counteract each other. This is also an issue when Arimidex is combined with Nolvadex.
This is another reason why combining either of these AIs with a SERM during PCT is not advisable at all – and since a SERM is basically essential for PCT it is going to take priority over either Letrozole or Arimidex. Both of these AIs offer far more advantages when their use is limited to during your steroid cycle where you can greatly benefit from their powerful anti-estrogen effects during that time.
Does Letrozole cause hair loss?
Some women who have used Letrozole for breast cancer treatment have experienced thinning of the hair – this is an expected effect on women who’s estrogen levels have been drastically reduced by the drug. This is not known to be an issue for male steroid users who take Letrozole, and hair loss is a much larger concern with the steroids themselves of which some can stimulate male pattern baldness because of an increase in dihydrotestosterone (DHT) as an androgenic side effect of steroid use.
What is the best time of day to take Letrozole?
There is no guide as to when steroid users should take Letrozole. For medical purposes it is taken once a day either morning or night. Whichever time you choose to take your daily dose it should be taken at a regular time each day or every other day depending on your preferred dose – so you are maintaining a balanced level of the drug in your system for maximum estrogen control.
Letrozole has a half life of two days and many steroid users will find that taking it every other day is best not only for results but also to reduce possible side effects (especially fatigue) from this powerful aromatase inhibitor.
Does Letrozole increase cholesterol?
Most aromatase inhibitor drugs will pose some risk to cholesterol health, in particular the lowering of good cholesterol levels while raising bad cholesterol and this is partly because of the lowering of estrogen – this is a hormone that plays a role in maintaining cholesterol health. Taking too high of a dose of Letrozole brings about the highest risk of this happening but most steroid users will only be using it at very low doses and for short periods of time.
Studies on the impacts of Letrozole on cholesterol have not been conclusive overall. One study found that cholesterol levels did rise after women used Letrozole for 6 months, but returned to normal when the drug was stopped. Another study showed that women on Letrozole for several years did not show any effects at all on cholesterol.
My Conclusion and Recommendation
Letrozole is possibly the most powerful aromatase inhibitor for preventing gyno and this should be your ultimate goal: to stop the condition from starting to develop at all while you’re using steroids. Prevention is better than cure when it comes to gyno, but if you do find that you’re starting to get those early signs then Letrozole has in some cases stopped them and reversed them.
Fully developed gyno can’t be reversed by Letrozole or any other drug (only surgery) but it is a very effective AI overall for gyno and other estrogen related effects.
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